Second Dose Interval

On 14 May 2021, the JCVI recommended that the second dose interval be brought forward from 12 to 8 weeks for people in priority cohorts 1-9 who have yet to receive their second dose. Operationally this means that second doses for cohorts 1-9 should take place at 56-63 days (8-9 weeks). The letter on accelerating second doses provides more information and can be found here. PCN and Community Pharmacy-led sites should draw down on all available support to offer the extra capacity required of their sites, working with CCGs/commissioners, ICSs and their Lead Employer who can help sites access national workforce supply routes.

For people in cohorts 10 onwards, the agreed dose interval period remains as previously, at 77-84 days (11-12 weeks) as outlined in the Chief Medical Officer’s letter.

Vaccine has been supplied for second dose clinics to take place 11 weeks post first dose clinics, so that the 12-week time period between doses is achieved. However, revised second dose supply delivery schedules will be issued to take account of the JCVI advice of 14 May referred to above. 2

Can clinics be scheduled early to vaccinate outside of the interval period?

Clinics should schedule second dose appointments in line with the recommended dosage intervals – 8-9 weeks (56-63 days) for people in priority cohorts 1-9 and 77-84 days (11-12 weeks) for people in cohorts 10 onwards – unless there are exceptional circumstances.

If, and by exception, there is vaccine at the end of a clinic which may be wasted, sites may bring forward cohort 10 onwards second doses (as per the Green Book). This should be as close to 12 weeks as possible and as a minimum at least eight weeks after the first dose as recommended by JCVI.

Are there any other circumstances when individual patients can receive their second dose outside of the standard interval period?

Patients should be offered to receive their second dose in line with the recommended dosage intervals – 8-9 weeks (56-63 days) for people in priority cohorts 1-9 and 77-84 days (11-12 weeks) for people in cohorts 10 onwards.